Volume 14, Number 2

AI-Assisted Early Diagnosis of Alzheimer’s Disease: A Clinical Evaluation of Machine and Deep Learning Models

Safdar Sardar Khan^1*, Rijvan Beg², Shredha Parmar¹, Mohammed Irfan Khan¹, Arpit Deo¹and Sadaf Akhtar¹

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Advancing Ethical Discourse in Neurotechnology: A Bibliometric Approach to Unveiling Research Frontiers

Ajay Kumar Dogra¹and Pooja Dogra^2*

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Alzheimer's Disease Classification Using Attention based 3D Convolutional Neural Network and 3 D MRI images

Upendra Singh^*, Vidit Kumar and Bhaskar Pant

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Multimodal Data Fusion in Mental Health: Integrating Behavioral Analytics with AI/ML for Enhanced Detection

Sushama Tanwar¹ , Prashant Vats^1*, Surbhi Sharma¹ and Kamal Upreti²

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Nanoparticles of Herbal Extracts in Treatment of Neurodegenerative Disorders

Ranajit Nath and Rajesh Ephraim Jesudasan^*

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Gene Editing in Neurological Disorders: Role of CRISPR-Cas9 in Targeted Therapies

Shaik Aminabee^*, Mittapalli Meghana Sri Naga Chaitanya, Mohammad Ayesha Begum, Sree Kavya Jonnalagadda, Mudunuri Syamala Devi, Polukonda Thanmai, Moka Bhagya Naga Deepika and Saladhi Veera Mounika Lakshmi

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A Scoping Review on the Future of Neurological Disorder Diagnosis: Artificial Intelligence and Machine Learning

Bhawna Chhabra¹, Malvika Kandpal⁵, Prince Raj², Arkan², Komal Kumari², Pushpanjali Kumari², Pankaj Pant⁴, Vikash Jakhmola³ and Mansi Butola²

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Crosstalk Between mTOR Signaling and Mitophagy Pathways: A Double-Edged Sword in PD

Ritika Sharma¹, Hitesh Dewangan^1* and Kundan Bora²

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Towards Intelligent Neurodiagnostic: A Systematic Assessment of EEG-Based Learning Models for Mental Illness Detection

Mohit Dayal^1*, Aparna Mahajan² and Manju Khari³

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Hybrid Approach for Classification and Segmentation of Brain Tumour

Gaurav Kumar Verma¹, Shailendra Kumar¹, Maninder Singh², Harsh Pratap Singh³, Arvind Mewada^4* and Mohd. Aquib Ansari⁵

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An Optimized EfficientNet-B0 Framework for Multi-Class Brain Tumour Detection and Classification from MRI Images

Mohammed Muddasir Naseer¹, Veeraprathap Veerabhadraiah², Basavaraj Rayappa Ramji³, Santhosh Kumar Kadur Lokeshappa⁴, Srividya Chandagirikoppal Nagendra⁵, Yathiraj Guduganahalli Ramesh⁶ and Kiran Puttegowda^7*

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Multi-Omics Cancer Subtyping with Robust Correlation, UMAP, and Topological Hypergraph Learning

Muneeba Afzal Mukhdoomi^* and Manzoor Ahmad Chachoo

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An Explainable AI-Based Ensemble Framework for Brain Tumor MRI Classification and Automated Clinical Reporting Using Deep Learning and LLM Integration

Kaliprasanna Swain¹, Soumya Ranjan Nayak^1*, Santosh Kumar Swain¹ and Prabhishek Singh²

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Enhanced Hybrid AI-Based Framework for Improving the Detection and Diagnosis of Alzheimer’s Disease

Tulip Das^1,3, Chinmaya Kumar Nayak² and Parthasarathi Pattnayak^3*

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Improving Diagnostic Accuracy in Brain Tumor Detection using EfficientNetB3 Transfer Learning and Support Vector Machine

Abhimanu Singh^1,2* and Smita Jain²

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Integrating AI with Neurogenetics: Applications in Precision Medicine for Neurological Disorders

Hriday Kumar Biswas¹, Kanhaiya Kumar Jha¹, Vikash Jakhmola², Srishti Morris^1*, Pallavi Pandey², Anshika Rawat¹ and Akanksha Kumari¹

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Perivascular Adipose Tissue: Implications for Cardiometabolic Diseases

Pages : 1765-1774

Rama Rao Nadendla^1*, Srismitha Settipalli², Sovan Bagchi³, Gunamoni Das⁴, Tamalika Chakraborty⁵, Tabinda Hasan⁶, Kumaraswamy Dabburu⁷ and Suria Prabha Kannaiyan⁸

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DOI : https://dx.doi.org/10.13005/bpj/3213

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768

Understanding Cellular Senescence and Senotherapeutics for Nutri-geriatric Solutions

Pages : 1775-1792

Sonam Chawla*, Sanjukta Bhattacharya and Aaysha Gupta

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DOI : https://dx.doi.org/10.13005/bpj/3214

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339

Evaluating Platelet Parameters in Diagnosis and Prediction of Preeclampsia among Pregnant Women

Pages : 1793-1800

Albadawi Abdelbagi Talha⃰, Yara Ahmad Albarrak, Norah Badr Alruwaili, Hadeel Abdurrahman Aldraan, Fai Fahad Al Shamari

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DOI : https://dx.doi.org/10.13005/bpj/3215

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286

From Spatial Domain to Learning Based Methods: A Survey on MRI and HRCT Image Denoising Methods

Pages : 1801-1823

Archana Saini^1*, Ayush Dogra²and Vinay Kukreja¹

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DOI : https://dx.doi.org/10.13005/bpj/3216

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273

Mechanistic Understanding of Finerenone in Hypertension Management: A Narrative Review

Pages : 1824-1834

Monisha Prasad¹, Sulthan Al Rashid², Vinjmur Ragavan Yashvanthan^2*, Bruhan Math Prakash³and Malarveni Damodaran Lakshmi Priya⁴

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DOI : https://dx.doi.org/10.13005/bpj/3217

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554

Topical Drug Delivery in Oral Mucosal Diseases: Challenges, Carriers, and Innovations: A Comprehensive Review

Pages : 1835-1848

Ahmed Shaher Alqahtani

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DOI : https://dx.doi.org/10.13005/bpj/3218

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504

Review on H3 Receptor Modulators: Future Pioneering approaches in Dementia Treatment

Pages : 1849-1862

Nagaraju Bandaru*, Mohiyuddin Ikramuddin Shaikh, Bagal Tanmay Yogendra, Wagh Sakshi Krishna, Krunal bhai Rameshbhai, Makarand Suresh Gambhire

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DOI : https://dx.doi.org/10.13005/bpj/3219

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243

A Comprehensive Review of US-FDA Novel Drug Approvals from 2013-2022: An Observational Study

Pages : 1863-1873

Ajay Kumar Shukla¹ and Saurav Misra^2*

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DOI : https://dx.doi.org/10.13005/bpj/3220

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297

A Comprehensive Review on Carbon Nanodots: From Synthesis to Applications

Pages : 1874-1888

Venkatesan Kotteeswaran^*, Sasi Kumar K, Mukhil M, Tarini Bardeja, Trisha Saha, R. Vasantha Narayanan, Ramakrishnan Govindaraj

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DOI : https://dx.doi.org/10.13005/bpj/3221

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310

Pharmacological Properties and Bioactive Compounds of Araucaria angustifolia: A Comprehensive Review

Pages : 1889-1907

Sibbala Subramanyam^1*, Kalaiah Gari Venkata Madhusudhan ², Surya Prabha Matangi¹, Ponnaiah Bharath Rathna Kumar³ and Janapati Pedda Yanadaiah⁴

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DOI : https://dx.doi.org/10.13005/bpj/3222

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261

Relationship Between Autoimmune and Metabolic Disease in Current Prospectus

Pages : 1908-1916

Rakhi Mishra, Guno Sindhu Chakraborthy^*and Rohit Agrahari

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DOI : https://dx.doi.org/0.13005/bpj/3223

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240

Metronomic Chemotherapy: An Alternative Strategy in Cancer Treatment Based on Continuous Low-Dose Administration

Pages : 1917-1924

Giorgio Attina’, Stefano Mastrangelo, Alberto Romano, Dario Talloa, Palma Maurizi and Antonio Ruggiero^*

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DOI : https://dx.doi.org/10.13005/bpj/3224

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250

Mental Health Treatment Prediction Using Machine Learning

Pages : 1925-1937

Chitra Retnaswamy, Anusha Bamini Antony Muthu*, Brindha Duraipandi and Rajeswari Manickam

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DOI : https://dx.doi.org/10.13005/bpj/3225

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272

Extended GnRH Agonist and NETA Add-Back: An Effective and Safe Option for Refractory Endometriosis/Adenomyosis Pain

Pages : 1938-1946

Moamar AL-Jefout¹, Shamsa Al Awar^1*, Samer Yaghi²and Omar Dabas²

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DOI : https://dx.doi.org/10.13005/bpj/3226

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235

Fecal Calprotectin and CRP: Noninvasive Biomarkers in IBD

Pages : 1947-1952

Hala Tabie El-Bassyouni¹, Dina Abdallah Nagi¹, Eman Refaat Youness^2*, Hisham Abdel Aziz Orban², Hend Mostafa Ahmed², Kamal Abdel Rahman El- Atrebi ³, Hanaa Reyad Abdallah⁴and Moushira Zaki⁴

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DOI : https://dx.doi.org/10.13005/bpj/3227

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193

Frequency of ACE I/D and PAI-1 4G/5G Polymorphisms in Women with Recurrent Pregnancy Loss in Sudan

Pages : 1953-1961

Asaad Babker^1*, Hanan Khalid Fadul Ahmed², Salaheldein Elzaki ², Shawgi Elsiddig³, Sarah Elsiddig Dafallah⁴, Tagwa Yousif Elsayed Yousif⁵, Elryah Ali ⁶, Maha Mahagoub Osman Mahagoub⁷ and Vyacheslav Lyashenko⁸

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DOI : https://dx.doi.org/10.13005/bpj/3228

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142

Candesartan Polymeric Microneedle Arrays: Design, Optimization, and Characterization Made with a 3D Fused Deposition Method

Pages : 1962-1974

Ola Ali Tarawneh ^1*, Yahia Fayiz Makableh², Ala Abdul Kareem Alhusban¹, Ahmad Mustafa Malkawi², Anas Mutawa Alhusban², Alghadeer Haider Al-Shammari¹and Mohammad Majed Hailat¹

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DOI : https://dx.doi.org/10.13005/bpj/3229

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145

Ultrasound-Based Non-Invasive Osteoporosis Detection Using Advanced Deep Learning Techniques

Pages : 1975-1990

Tamilselvi Rajendran^*, Parisa Beham Mohamed, Sathiya Pandiya Lakshmi, Nandhineeswari and Shanmuga Priya

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DOI : https://dx.doi.org/10.13005/bpj/3230

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169

Endophytic Bacteria from Lannea coromandelica for Enhancing Silver Nanoparticle Biosynthesis

Pages : 1991-1999

Yusminah Hala, A Irma Suryani*, Muhammad Junda, Hartono, Rachmawaty Muhtar, Andi Annisa and Andi Fahirah

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DOI : https://dx.doi.org/10.13005/bpj/3231

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161

Oral Contraceptives and Hypertension Risk: Implications for Cardiovascular Health and Clinical Management

Pages : 2000-2013

Umesh Laddha, Gayatri Kotwal, Akshada Jadhav, Devyani Patil and Gangadhar Magar*

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DOI : https://dx.doi.org/10.13005/bpj/3232

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298

Gene Expression Data-Based Interpretable Machine Learning Framework for Classifying Brain Cancer Subtypes

Pages : 2014-2023

Virendra Singh Kushwah¹, Sivaneasan Bala Krishnan², Kamal Upreti^3*, Pravin Kshirsagar⁴, Manoj Kumar⁵, Uma Shankar⁶and Ganesh Veluswamy Radhakrishnan⁷

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DOI : https://dx.doi.org/10.13005/bpj/3233

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149

Functional Analysis of RHOU and PADI6 Genes in Basal Cell Carcinoma: Insights from Genome-Wide Association Studies

Pages : 2024-2036

Usha Adiga^1*, Sampara Vasishta², Amulya Tunuguntla¹, Tulasi Govardhan³and Kasala Farzia¹

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DOI : https://dx.doi.org/10.13005/bpj/3234

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121

Preliminary Study of Ethno-medicinal Practices of the Tea Tribes in Titabor Sub-division of Jorhat District, Assam.

Pages : 2037-2049

Manas Das and Aashis Dutta*

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DOI : https://dx.doi.org/10.13005/bpj/3235

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163

Clustering Medical Conditions in Patient Records Using Unsupervised Learning Techniques: A Comparative Study

Pages : 2050-2060

Bhupesh Rawat¹^∗, Himanshu Pant¹ and Ankur Bist²

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DOI : https://dx.doi.org/10.13005/bpj/3236

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325

AI-Integrated Digital Auscultation System for Early Detection and Monitoring of Chronic Obstructive Pulmonary Disease in Resource-Limited Settings

Pages : 2061-2069

Sindu Divakaran¹, Hari Krishnan Gurumurthy^2*, Mohandass Ganapathy¹, Sudhakar Tukkaram¹and Bethanney Janney John³

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DOI : https://dx.doi.org/10.13005/bpj/3237

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273

Molecular Modelling Study of Cofilin Dimer Inhibitors in Cognitive Decline

Pages : 2070-2082

Magesh Mohan¹, Renukadevi Jeyavelkumaran^2*, Vijayakumar Balakrishnan³and Sanjay Valliappan²

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DOI : https://dx.doi.org/10.13005/bpj/3238

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138

Recent Advancements in the Bio-medical Implant Production using Additive Manufacturing – Comparison, Challenges and Future Scope

Pages : 2083-2101

Madhanagopal Manoharan^1,2*, Bhavadharani Babu³, Sindu Divakaran³, Gobi Saravanan Kaliaraj², Perumal Sudalai⁴,and Rajendra Thilahar Chelladurai⁵

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DOI : https://dx.doi.org/10.13005/bpj/3239

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181

Evaluation of Anti-Hemorrhoidal Activity and Phytochemical Study of Zidarga-6 Capsule

Pages : 2102-2112

Chimedragchaa Chimedtseren¹, Dejidmaa Buyantogtokh^1*, Myadagbadam Urtnasan², Anu Altangerel¹, Uuganbayar Baatartsogt¹and Erdenechimeg Chuluunbaatar²

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DOI : https://dx.doi.org/10.13005/bpj/3240

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203

Chemical Composition and Bioactive Constituents of Standardized Ginger (Zingiber officinale Rosc.) Simplicia

Pages : 2113-2132

Sentot Joko Raharjo^1*, Dewi Ratih Tirto Sari² Ernanin Dyah Wijayanti³ and Yanty Maryanty⁴

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DOI : https://dx.doi.org/10.13005/bpj/3241

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363

Exploring Medicinal Plants as Natural Inhibitors of Collagenase, Elastase, and Hyaluronidase: A Novel Approach for Cosmeceutical Innovation

Pages : 2133-2149

Rajesh Dattatray Tak^1*, Ajit Babruwahan Patil^1,2, Bhimrao Vishwanath Jaiwal² and Yuvraj Prakash Kale²

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DOI : https://dx.doi.org/10.13005/bpj/3242

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257

Extracting an Extremely Corrupted ECG Signal

Pages : 2150-2163

Abdulkareem Mokif Obais

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DOI : https://dx.doi.org/10.13005/bpj/3243

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209

Ameliorative Effects of Cassia fistula Pod Extract on Testicular Histopathology, Oxidative Stress and Reproductive Hormone Levels in Streptozotocin Induced Diabetic Rats

Pages : 2164-2178

Ram Niwas Jangir^*, Gyan Chand Jain, Aditya Jainand Tanvi Jangid

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DOI : https://dx.doi.org/10.13005/bpj/3244

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185

Comparing Progressive Muscle Relaxation and Neural Mobilization for Tension-Type Headaches: A Randomized Comparative Study on Pain and Stress Reduction

Pages : 2179-2186

Kamatchi Kaviraja¹*, Bhuvana Kumar¹, Kaviraja Natarajan²and Tanya Bernadite Arokiaraj¹

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DOI : https://dx.doi.org/10.13005/bpj/3245

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177

Recent Clinical Advancements in Immunotherapy for the Management of Breast Cancer

Pages : 2187-2201

Utkarsh Upadhyay¹, Vivek Srivastava^1*, Neha Mathur¹ and Somesh Thapliyal²

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DOI : https://dx.doi.org/10.13005/bpj/3246

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151

Screening of Traditional Chinese Medicine (TCM) Compounds for their Aromatase Inhibitory Potential by Applying Molecular Docking, Dynamics Simulation and Cytotoxicity Assay

Pages : 2202-2213

Hasanain Abdulhameed Odhar

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DOI : https://dx.doi.org/10.13005/bpj/3247

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145

In-Silico and In-Vitro Evaluation of Vindoline as a Potential Anti-Inflammatory Agent Targeting COX-2 and NF-κB

Pages : 2214-2227

Preeti Chaudhary^*, Akash Kumavat, Pritam Khandave, Rupesh Pingale, Sakshi Singh, Omkar Dudhal, Sonali Korlekar and Shubham Tivlekar

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DOI : https://dx.doi.org/10.13005/bpj/3248

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205

Potential of Cersenlau Sugar as a Therapeutic Sugar Agent: Evidence from Rat Models and Healthy Adults

Pages : 2228-2238

Ni Nyoman Budiani^*, Lely Cintari, Ni Komang Wiardani, Listina Ade Widya Ningtyas and Gusti Ayu Tirtawati

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DOI : https://dx.doi.org/10.13005/bpj/3249

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207

Therapeutic Potential of Red Ginger (Zingiber officinale var. Rubrum) Bioactive Compounds in Obesity-Associated Metabolic Parameters of Wistar Rats.

Pages : 2239-2248

Ni Wayan Bogoriani^1*, I Gusti Ayu Putu Eka Pratiwi², Ni Wayan Mirawati³, Ida Ayu Raka Astiti Asih⁴and Komang Tria Noviana Dewi⁵

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DOI : https://dx.doi.org/10.13005/bpj/3250

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331

In Vitro Antibacterial Efficacy of Crude Leaf Extracts from Catharanthus roseus: A Natural Therapeutic Prospect

Pages : 2249-2257

Nazeerullah Rahamathullah^1,2, Sovan Bagchi¹, Manisha Nanda^3,4 and Abhaya Dutta^5*

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DOI : https://dx.doi.org/10.13005/bpj/3251

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216

PCOS Detection using Hybrid CNN-XGBoost Model - A Multimodal Data Approach

Pages : 2258-2269

Shital Pawar, Pratik Dhane, Dhanraj Shelke*, Prashant Dheple and Nisarg Doshi

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DOI : https://dx.doi.org/10.13005/bpj/3252

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295

Natural Wisdom in Blood Sugar Regulation: Investigating Trigonella foenum-graecum and Olea europaea

Pages : 2270-2276

Amjed Haseeb Khamees^* and Nabba Mohammed Ibrahim

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DOI : https://dx.doi.org/10.13005/bpj/3253

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204

Finite Element Analysis of Proximal Femur Fractures: Evaluating Fatigue Performance and Factor of Safety of DHS Screw Fixation

Pages : 2277-2289

Aashish Joshi^1,2*, Kailash Karande²and Ravindra Gunaki³

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DOI : https://dx.doi.org/10.13005/bpj/3254

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161

Ki-67 Expression as a Biomarker for Aggressiveness and Therapeutic Response in Non-Hodgkin's Lymphoma

Pages : 2290-2297

Ngakan Ketut Wira Suastika^*and Ketut Suega

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DOI : https://dx.doi.org/10.13005/bpj/3255

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148

Evaluation of Quercetin on Proinflammatory Cytokines Against Klebsiella pneumoniae in Mice

Pages : 2298-2304

Ikram Abbas Aboud Al-Sammaraae

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DOI : https://dx.doi.org/10.13005/bpj/3256

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110

Chemopreventive Effect of Gliricidia sepium Plant Extracts in MNU Induced Mammary Tumor Model

Pages : 2305-2314

Sudhir Patil^{1, 2*}and Kiran Wadkar³

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DOI : https://dx.doi.org/10.13005/bpj/3257

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159

Biopolymer (Polyhydroxybutrates) Production from Promising Haloarchaea: Characterization, Optimization with in Vitro Cytotoxic Activity

Pages : 2315-2326

Nuha Khalid Neyazi^1*, Hend Maarof Tag^2,3, Naglaa Elshafey⁴and Nashwa Hagagy^1,5

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DOI : https://dx.doi.org/10.13005/bpj/3258

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139

Pharmacological Treatment of Mental Disorders and the Prevalence of Antipsychotic Drug Use at the Mental Health Center in Pristina

Pages : 2327-2335

Fitim Alidema¹, Dia Balidemaj², Arieta Hasani Alidema¹, Lirim Mustafa^1*, Albulena Jashari Selmani⁵, Mirlinda Havolli³and Fellenza Abazi³

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DOI : https://dx.doi.org/10.13005/bpj/3259

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162

Perceptions and Experiences of Indian Traditional Medicine Practitioners in Managing Epilepsy: A Qualitative Study in Malaysia

Pages : 2336-2345

Siti Nor Aqilah Mohd Noor¹, Shazia Jamshed², Chiau Ming Long³, Umar Idris Ibrahim¹, Ahmad Kamal Ariffin Abdul Jamil¹, Nurulumi Ahmad¹, Aslinda Jamil¹, Kheng Seang Lim⁴and Pei Lin Lua^1*

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DOI : https://dx.doi.org/10.13005/bpj/3260

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Antimicrobial and Antiproliferative Assessment of Formulation from Zanthoxylum armatum

Pages : 2346-2356

Kunal Sharma¹, Neha Pandey¹, Madhulika Ether Prasad³, Atal Bihari Bajpai⁴and Amit Gupta^2*

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DOI : https://dx.doi.org/10.13005/bpj/3261

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125

Expert-Based Content Validation of a Culturally Adapted Therapeutic Education Workbook for Gestational Diabetes in Moroccan and Arabic-speaking Contexts

Pages : 2357-2374

Abdelhaq Barbach^1*, Youssef Ikken^2,3, Yahya Charrah^1,4, Anas Ansari Chenguiti^1,4,5, Ouiam Dahmane¹, Rachid Alami⁶and Amina Barkat^1,4,7

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DOI : https://dx.doi.org/10.13005/bpj/3262

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116

Evaluation of Antioxidant and Cytotoxic Potentials against the EAC cell line of Aqueous Extract of Annona reticulata Linn.leaves

Pages : 2375-2393

Tasnia Binte Bari Kabbo¹, Pritesh Ranjan Dash^1,2, Adila Jahan Anika³, Najiha Tarannum Timon³, Tasnova Nowrin⁴, Shammi Binte Bashar² and Md. Sohel Rana^1*

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DOI : https://dx.doi.org/10.13005/bpj/3263

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