eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 1849 1862 10.13005/bpj/3219 67128 article Nagaraju Bandaru 1 Mohiyuddin Ikramuddin Shaikh 1 Bagal Tanmay Yogendra 1 Wagh Sakshi Krishna 1 Krunal bhai Rameshbhai 1 Makarand Suresh Gambhire 1 Department of Pharmacology, School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik,, Maharashtra, India. Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression. There has been an elevating concern in recent years targeting Histamine H3 receptor in treating cognitive disorders, including dementia. Preclinical studies have shown that antagonists of H3 receptor or inverse agonists enhances the cognitive function in animal models with dementia by increasing the release of neurotransmitters associated with learning and memory. The primary aim of this study is to explore the pathophysiological mechanisms underlying Alzheimer’s disease (AD), with a specific focus on the role of the histamine H3 receptor (H3R) and its modulators. This review employed a systematic literature search across databases including PubMed, Scopus, Google Scholar, and ClinicalTrials.gov, selecting peer-reviewed studies published between 2000 and 2024. Results of the study illustrate the complex landscape of research on H3 receptor modulators in dementia, highlighting both promising findings and ongoing challenges in translating preclinical discoveries into effective clinical interventions. Knowing the Histamine H3 receptors role in dementia and developing novel pharmacological interventions targeting these receptors represent a promising avenue for future research leading to new treatments development to this devastating condition. https://biomedpharmajournal.org/vol18no3/review-on-h3-receptor-modulators-future-pioneering-approaches-in-dementia-treatment/ Dementia Findings Histamine Modulators Receptors Research