eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 2975 2984 10.13005/bpj/3310 69373 article Guli Raimova 1 Siroj Khodjiyev 1 Kabil Nasirov 1 Nozim Khoshimov 1 Mukhamatkodir Ortikov 1 Alisher Mukhtorov 3 Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, Uzbekistan Department of Protein and Peptide Chemistry, Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan Department of Human and Animal Physiology, Nаtiоnаl Univеrsitу оf Uzbеkistаn named after M. Ulugbek,Tashkent, Uzbekistan Department of Pedagogical of preschool education of Chirchik State Pedagogical University, Chirchik, Uzbekistan Department of Pedagogical University named after Nizam, Tashkent State, Uzbekistan In type 2 diabetes mellitus, all hemostatic systems involved in blood clotting, regulation of vascular tone, the condition of blood cells, and plasma enzyme systems are activated. In this disease, there is a clear correlation between hemocoagulation disorders and the degree of glycemia. In this regard, an important and urgent task is to study these mechanisms and to search for new drugs that can prevent further progression. In this study, experiments on model rats were conducted to test the effects of polyphenols as antidiabetic agents. Polyphenol-containing foods and beverages such as coffee, guava tea, blueberries, olive oil, propolis, chocolate, red wine, grape seeds, and cocoa have been shown to exert beneficial effects in individuals with type 2 diabetes mellitus. These compounds contribute to better glucose regulation, enhance vascular health, reduce insulin resistance, and help lower HbA1c levels, thereby potentially mitigating both the progression and complications of diabetes, including alterations in the hemostatic system. This paper presents a study of polyphenol preparations isolated from the Pistacia vera plant (compound ANK-1), the Karelinia caspia plant (compound KCL-1), and an extract from the Isatis tinctoria L. plant (compound ITL-2), and their effects on biochemical parameters and the blood-clotting system in rats with experimentally induced type 2 diabetes caused by streptozotocin. https://biomedpharmajournal.org/vol18no4/effect-of-polyphenols-on-the-hemostatic-system-in-rats-with-streptozotocin-induced-type-ii-diabetes/ Anticoagulants Fibrinogen Hemostatic system Polyphenols Streptozotocin Type 2 diabetes mellitus