eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 3213 3224 10.13005/bpj/3329 69332 article DA WA 1 Dejidmaa Buyantogtokh 3 Erdenechimeg Chuluunbaatar 4 Chimedragchaa Chimedragchaa 3 Tsend-Ayush Damba 5 Department of Internal Medicine, International school of Mongolian medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia, Department of Gal zasal, Inner Mongolia International Mongolian Hospital, Hohhot, China Department of Pharmacology, Research Center, Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia, Department of Chemistry and Technology, Research Center, Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia, Department of Mongolia Medicine Study, Institute of Traditional Medicine and Technology of Mongolia, Ulaanbaatar, Mongolia In Mongolian traditional medicine, Sapparin tablets are used to treat blood disorders and liver diseases. These tablets consist of four main ingredients: C. jubata, C. sappan, Z. officinale, and H.rhamnoides. This study evaluates the antihyperglycemic and anticoagulant effects of Sapparin tablets in a T2DM induced by streptozotocin and a high-fat food. Forty rats were divided into 4 groups (n = 10): normal control, diabetic control and two groups of Sapparin.  Wistar rats were fed a high-fat diet at a rate of 40 grams per day for 28 days. On the 29th day, after fasting for 18 hours, the rats were intraperitoneally injected with streptozotocin at a dose of 35 mg/kg. Following this, two different doses of Sapparin (89 mg/kg and 178 mg/kg) were administered to the T2DM (type 2 diabetes mellitus) rats via oral gavage. The experimental results indicated that Sapparin significantly reduced fasting glucose levels, fasting blood insulin, triglycerides, cholesterol, and HDL. We demonstrated that Sapparin effectively alleviates diabetic symptoms by lowering fasting glucose and insulin levels while increasing GLUT4 levels. Additionally, Sapparin protects against insulin resistance, enhances superoxide dismutase activity, and improves lipid profiles in rats with type 2 diabetes mellitus https://biomedpharmajournal.org/vol18no4/evaluation-of-the-antihyperglycemic-and-anticoagulant-effects-of-sapparin-tablets-in-streptozotocinhigh-fat-diet-induced-diabetic-rats/ Antidiabetic C.Jubata C.Sappan Z.Officinale H.rhamnoides T2DM