eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 3038 3048 10.13005/bpj/3316 68221 article Umamaheswari Duraisamy 1 Kumar Mohan 1 Anand Sanjay Kamaraj 1 Sudharsan Jayasankar 1 Thirumoorthy Poomalai 1 Vignesh Ezhilarasan 1 Department of Pharmaceutical Analysis, Vinayaka Mission’s College of Pharmacy, VMRF (DU), Salem, India The goal of this study was to create and evaluate dispersible aspirin tablets in order to increase patient compliance, especially for those who have difficulty swallowing regular pills. Aspirin, a widely used analgesic and anti-inflammatory medicine, frequently causes stomach discomfort in its standard form. Dispersible pills have the potential to improve stomach tolerance and have a quicker onset of action. To achieve rapid dispersion in water, relevant excipients such as Disintegrants, binders, and diluents were added to the direct compression method utilised in the tablet and wet granulation procedures. The physicochemical characteristics of the produced tablets, such as weight variation, hardness, friability, disintegration time, and homogeneous drug content, were assessed. After optimization, the tablet characteristics exhibited promising results, releasing more than 85% of the drug after 30 minutes and dispersing in less than 3 minutes.  There may be quicker absorption and therapeutic benefits as a result of this rapid disintegration and dissolving profile. Expedited stability testing found no noticeable modifications in the tablet’s chemical and physical features throughout a three-month period. Dispersible aspirin tablets are a potential dose form that provide a practical and efficient substitute for conventional aspirin tablets, according to the study’s findings. This formulation strategy may help increase patient compliance, especially in the case of elderly and paediatric patients, as well as those who have swallowing issues. https://biomedpharmajournal.org/vol18no4/formulation-and-quality-control-test-for-fast-dispersible-aspirin-tablets/ Aspirin Disintegration time Fast dissolving Oral dispersible tablet Pre-formulation Swallowing