eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 1908 1916 0.13005/bpj/3223 66991 article Rakhi Mishra 1 Guno Sindhu Chakraborthy 2 Rohit Agrahari 3 Parul Institute of Pharmacy & Research, Faculty of Pharmacy, Parul University, Vadodara, Gujarat, India Stoutness is a chronic metabolic syndrome that occurs due to overeating and lack of energy expenditure in the form of any physical exercise, the indication of stoutness is being overweight, an increase in abdomen circumference, and various socioeconomic factors. Stoutness is related to multiple diseases such as hyperlipidemia, hypertension, and type 2 diabetes mellitus. The indication of stoutness is observed by elevation in body weight and increase in circumference of the abdomen. Thyroid and stoutness have similarities in them such as increased body weight and it also causes slow metabolism which causes weight gain which leads to obesity it also causes inflammation in the body which is also a major factor of obesity. This article also discusses the role of leptin in obesity and thyroid, where there is a correlation in terms of some receptors involved in them. It also contains the inflammation role in stout and thyroid dysfunction. Generally, in the thyroid, the inflammation of the thyroid gland and the neck circumference is noted, and insulin resistance is also there. A study suggested all the aspects. Due to stoutness a resistance to thyroid hormone is also studied and all the aspects suggested in the article there are also changes occur in adipose tissue which is a major factor in stoutness and is also correlated with a thyroid disorder, adipose tissue is also indirectly correlated with energy expenditure. In this article, we discuss all the possible parameters and factors that are involved in stoutness and thyroid dysfunction. https://biomedpharmajournal.org/vol18no3/relationship-between-autoimmune-and-metabolic-disease-in-current-prospectus/ Adipose Tissue Hypertension Hyperleptinemia Inflammation Metabolic Syndrome Stoutness Thyroid Dysfunction