eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 1962 1974 10.13005/bpj/3229 67440 article Ola Ali Tarawneh 1 Yahia Fayiz Makableh 2 Ala Abdul Kareem Alhusban 1 Ahmad Mustafa Malkawi 2 Anas Mutawa Alhusban 2 Alghadeer Haider Al-Shammari 1 Pharmacy Department, Al-Zaytoonah University of Jordan, Amman, Jordan. Department of Nanotechnology, Jordan University of Science and Technology, Irbid, Jordan. Microneedle arrays are a simple, noninvasive transdermal delivery system. The technique's preparation, optimization, and scaling up are all active research topics. This paper investigates a simple method for making microneedle molds for inverted-solvent casting preparation of microneedle arrays. The effect of different resins and printing conditions on the geometry of microneedle arrays was investigated using stereolithography 3D printing. Four molds prepared in this study were selected to be filled with candesartan cilexetil in a mixture of polymers that include EMPROVE^® and gantrez. The fully formed MNAs were evaluated based on skin perforation, drug release through Franz cells, bending ability, and sterilization. The model drug and the resultant MNAs were evaluated based on the MNA's shape, drug release, and compression resistance. To improve process quality and achieve highly aligned defect-free needles, the surface of the fabricated microneedles was modified with a monolayer of hyaluronic acid. The structure design was optimized using computer-aided design. The molds were tested by producing candesartan cilexetil microneedle array patches for transdermal delivery. This study discovered that hot plate post-treatment and avoiding shear force during mold peeling are critical for fabricating high-quality arrays. Candesartan cilexetil microneedles were successfully prepared, and the release rate was 73.36 ± 7.29% of the loaded candesartan cilexetil amount over 24 hours. The obtained molds can potentially be used to fabricate microneedle arrays successfully. https://biomedpharmajournal.org/vol18no3/candesartan-polymeric-microneedle-arrays-design-optimization-and-characterization-made-with-a-3d-fused-deposition-method/ Candesartan Cilexetil 3D printer Fused Deposition Hyaluronic Acid Microneedle Arrays Mold