eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 3087 3101 10.13005/bpj/3320 69442 article Aziza Azimova 1 Ibrohim Asqarov 3 Akmal Islomov 3 Arofat Inkhonova 4 Uchqun Ishimov 3 Lazizbek Makhmudov. 3 Dept. of Chemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan Dept. of Chemistry, Andijan State University, Andijan, Uzbekistan Dept. of Physicochemical Methods of Research, Proteins and Peptides, and Pharmacology, A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Uzbekistan Dept. of Pharmacy, Alfraganus University, Tashkent, Uzbekistan Dept. of Chemical Engineering, Jizzakh Polytechnic Institute, Jizzakh, Uzbekistan Dept. of Technology of purification of natural gas Tashkent Institute of Chemical Technology (TICT) Tashkent, Uzbekistan, This study investigates the chemical composition and pharmacological properties of Vitis L. seed extracts, highlighting their potential as natural therapeutic agents. High-performance liquid chromatography (HPLC) revealed that the extracts contain essential amino acids (proline, phenylalanine, threonine), simple carbohydrates (fructose, glucose), and several water-soluble vitamins (C, B1, B6, B9, B12). Spectroscopic analyses (FTIR and UV-Vis) confirmed the presence of hydroxyl, carbonyl, and aromatic groups characteristic of polyphenols, with UV absorption bands suggesting resveratrol and related flavonoids. In vivo acute toxicity testing demonstrated that the extracts are safe at doses up to 2000 mg/kg, with no mortality or notable physiological disturbances, classifying them as practically non-toxic. Anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model, where the seed extract produced a dose-dependent inhibition of inflammation. The 200 mg/kg dose showed an anti-inflammatory effect comparable to indomethacin. The findings indicate that Vitis L. seed extracts possess a favorable safety profile and notable anti-inflammatory potential. These characteristics support their prospective use in nutraceutical and pharmaceutical formulations aimed at managing oxidative stress and inflammation-related conditions. https://biomedpharmajournal.org/vol18no4/chemical-profile-and-anti-inflammatory-effects-of-taifi-grapes-vitis-l/ Anti-inflammatory activity Grape seed extract Phytochemical analysis Resveratrol Vitis L.