eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 1793 1800 10.13005/bpj/3215 67873 article Albadawi Abdelbagi Talha⃰ 1 Yara Ahmad Albarrak 1 Norah Badr Alruwaili 1 Hadeel Abdurrahman Aldraan 1 Fai Fahad Al Shamari 1 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences - Jouf University Despite the awareness and follow-up of pregnant women in modern obstetrics, preeclampsia (PE) remains a threat to the life of the mother and their fetus. The aim is to assess the platelet indices (MPV, PDW and PCT) in diagnosis and prediction of preeclamptic women. It is a retrospective case–control study was done in Sakaka, Aljouf region, Saudi Arabia; the data was taken from the patient’s records during the period of September – December 2023. In this study, we recruited 88 women with PE and equal controls. The data collected was analyzed using SPSS program version 20. The p<0.05 was set as statistical significance. The result showed that the MPV, and PDW were significantly higher in cases when compared with the healthy group (MPV 10.1±2.4 fl versus 8.6±1.3 fl, p < 0.001., and PDW 15.8±1.4% versus 13.8±2.3% p < 0.001), while the platelet count (PC) and plateletcrit (PCT) were significantly lower than that of the healthy group (PC 178.1±60.7 X 10⁹/L versus 282.2±77.0 X 10⁹/L, p < 0.001 and PCT 0.14±0.04% versus 0.22±0.5% p < 0.001). The ROC curve analysis of platelet parameters indicated that the PC had the highest area under the curve, which was 0.92 (95% CI 0.88-0.97), followed by MPV 0.83 (95% CI 0.75-0.90). The study concludes that the PC ≤175.0 x 109/L and MPV value ≥10.7 fl are reliable predictors of PE. https://biomedpharmajournal.org/vol18no3/evaluating-platelet-parameters-in-diagnosis-and-prediction-of-preeclampsia-among-pregnant-women/ Preeclampsia Pregnancy Platelets parameters Sakaka Saudi Arabia