eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 3070 3086 10.13005/bpj/3319 69289 article Hydar Saadi Hassan Al-Wasti 1 Anatomy Department, College of Medicine, University of Baghdad, Iraq This study presents a CFD-based biomechanical simulation of pulsatile blood flow in a stenosed right coronary artery (RCA) under three physiological conditions, i.e. standing, walking, and running. With the patient-specific geometry and pulsatile boundary conditions, velocity distribution, pressure gradients, wall shear stress (WSS) and arterial wall deformation were investigated. The study results indicated that there were changes in hemodynamics with an increase in level of activity. At standing speed (70 bpm), Mean blood velocity ranged between 0.2-0.5 m/s, the mean pressure was approximately 95 mm Hg systolic, wall deformation 0.11-0.12 mm. Velocities in walking (100 bpm) were raised to ~1.1 m/s, mean pressure to 105 mm Hg, deformation reached 0.14-0.15 mm. The hemodynamic load was highest at running (150 bpm) with velocities of 2.21-2.3 m/s, mean pressure up to 120 mm Hg, outlet velocity: 0.70-0.80 m/s, WSS: more than 10 Pa, and Deformation: 0.18 mm (60 percent increase compared to standing). These results indicate that increased physical activity is markedly augmented in coronary hemodynamic stresses and arterial wall reactions that could affect vulnerable plaque and stenosis progression. These findings may help improve diagnostic accuracy and individualized treatment planning for coronary artery disease. https://biomedpharmajournal.org/vol18no4/numerical-cfd-simulation-of-pulsatile-blood-flow-in-stenosed-coronary-arteries-under-different-physical-conditions-walking-running-and-standing/ Arterial Wall Deformation Computational Fluid Dynamics Coronary Artery Disease Physical Activity Pulsatile Blood Flow Wall Shear Stress