eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 3204 3212 10.13005/bpj/3328 69230 article Ikhtiyor Ikromovich Latipov 1 Dildora Abdumalikovna Nabieva 2 Miyassar Babakulovna Dzhabbarova 3 Ozodzhon Ilkhomovich Ergashov 4 Tokhir Erkiniy Rakhimzoda 5 Shukhrat Farkhodovich Ramazonov 6 Department of dermatology of Bukhara state medical institute by named Abu Ali Ibn Sino, Bukhara, Uzbekistan Department of 1st Faculty and Hospital Therapy with Occupational Pathology Tashkent state medical university, Tashkent, Uzbekistan. Department of Rehabilitation sports medicine of Bukhara state medical institute by named Abu Ali Ibn Sino, Bukhara, Uzbekistan. Department of Scientific Research of Tashkent scientific research institute of vaccines and serums, Tashkent, Uzbekistan. Department of 1st Faculty and Hospital Surgery of Tashkent State Medical University, Tashkent, Uzbekistan. Department of Rehabilitation and sports medicine of Bukhara state medical institute by named Abu Ali Ibn Sino, Bukhara, Uzbekistan. The increased incidence of mental and emotional disorders against the background of ChLD, leading to disability and death due to its severe complications, in turn, leads to a further exacerbation of the existing problem. The high prevalence of depressive states in patients with ChLD compared with healthy people and the hepatotoxicity of existing antidepressants make it imperative to search for hepatoprotectors and antidepressants with a less toxic natural base. In this regard, the main purpose of the presented manuscript is to determine the hepatoprotective and antidepressant activity of the vegetable oil of Iceland in the study conditions. Studies to detect hepatoprotective activity were conducted on white rats and ChTLD was caused by oral administration of 500 mg/kg of pratacetamol and 1 ml of 40% ethanol for two weeks. On the other hand, the hepatoprotective activity of the test substance was assessed by blood biochemical parameters, the amount of bile secretion and its effect on its composition, and the antidepressant activity was realized in white mice using methods C. Hall, R. Porsolt and L. Steru. In the conducted studies, IVO was studied in doses of 100; 150 and 200 mg/kg, which showed high activity in stabilizing biochemical parameters disrupted by chronic administration of toxic substances, normalizing the excretion of bile and its components. It was found that the vegetable oil studied for this activity showed pronounced activity compared to the control dose and lower activity compared to the dose of phosphogliv 50 mg/kg, while apkosul showed similar activity compared to the dose of 100 mg/kg. In addition, the experimental animals showed clear depressive activity due to improved motor and search activity, increased forced swimming time and decreased immobilization time, and in terms of this activity, the comparative drug is not inferior to the studied dose of fluoxetine 10 mg/kg. The results obtained on the basis of research, in turn, dictate the need for large-scale physico-chemical studies based on this vegetable oil in order to obtain separately bioactive phytocomponents for the initial determination of their components.  However, structural studies of this vegetable oil may lead to a further expansion of the range of PhTS. https://biomedpharmajournal.org/vol18no4/investigation-of-hepatoprotective-and-antidepressant-activity-of-oil-extracted-from-the-iceland-plant-in-experimental-animals-under-study-conditions/ Apkosul Fluoxetine Iceland roses Icelandic vegetable oil Immobilization Phosphogliv