Krishna P. S, Shankar K. A, Babu N. A, Masthan K. M. K. Cyclin B in Oral Squamous Cell Carcinoma –Mini Review. Biomed Pharmacol J 2015;8(October Spl Edition)

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Published online on: 20-01-2016

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P. Sai Krishna¹, K. A Shankar¹, N. Aravindha babu², K. M. K Masthan²

¹Tagore dental college and Hospital, Chennai, Tamilnadu, India. ²Sree Balaji Dental College and Hospital, Bharath University, Chennai.

DOI : https://dx.doi.org/10.13005/bpj/653

Abstract

Oral squamous cell carcinoma accounts for more than 50% of all tumours in India due to the increased use of tobacco and its products. The most common cause of mortality in OSCC is due to the local recurrence and regional and distant nodal metastasis, thus necessitating the need for proper therapy. Cyclins are a family of proteins that a play an important role in the cell cycle and its regulation. Cyclin B which belongs to the group of  M cyclins is responsible for the G2/M transition and also the mitotic process. Cyclin B1 has been implicated in many cancers including Oral squamous cell carcinoma. Cyclin B2 which is coexpressed along with cyclin B1 is relatively less known. Cyclin B2 can act in the absence of cyclin B1 and vice versa too. Cyclin B1 can induce golgi fermentation faster than cyclin B2. Cyclin B2 can cause the progression of cell to undergo mitosis in the absence of cyclin B1. So in cancers both the cyclins play an important role. Targeted therapies have earlier targeted only the cyclin dependent kinases in the cyclin B1-Cdk complex. But now research is on to directly act against cyclin B. This mini review brings to light the role and expression of cyclin B in oral squamous cell carcinoma.

Keywords

Cell cycle; check points; cyclin B; M phase factor; cyclin B1; cyclin B2