Bose B. B, Babu N. A, Masthan K. M. K. Is Resistin A Biomarker for Periodontitis - An Insight. Biomed Pharmacol J 2015;8(October Spl Edition)

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Manuscript received on :
Manuscript accepted on :
Published online on: 19-01-2016

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Bhuvaneswari Birla Bose¹, N. Aravindha Babu², K. M. K. Masthan²

¹Department of Periodontics, Tagore Dental College and Hospital. ²Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University , Chennai.

DOI : https://dx.doi.org/10.13005/bpj/666

Abstract

Resistin is a recently discovered adipocytokine, having a potent biomarker quality. Initially resistin was thought to be produced by adipocytes alone; however, emerging evidence suggests that it is also produced in abundance by various cells of the immunoinflammatory system, indicating its role in various chronic inflammatory diseases. Data suggests that resistin plays a role in obesity, insulin resistance, cardiovascular diseases, and periodontitis. Resistin derived its name from the original observation that it induced insulin resistance (resist-in: resist insulin) in mice and is downregulated in mature murine adipocytes cultured in the presence of insulin sensitizing drugs like thiazolidinediones. It is well recognized that obesity, is associated with insulin resistance and diabetes. Research shows incremental elevation of resistin with periodontal disease activity and a reduced level of resistin, after periodontal therapy. Thus resistin would be one of the molecular links connecting obesity, periodontitis, and diabetes and may serve as a marker that links periodontal disease with other systemic diseases.

Keywords

Resistin; adipocytokine; periodontitis; obesity; biomarker