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  <record>
    <language>eng</language>
          <publisher>Oriental Scientific Publishing Company</publisher>
        <journalTitle>Biomedical and Pharmacology Journal</journalTitle>
          <issn>0974-6242</issn>
            <publicationDate>2016-12-22</publicationDate>
    
        <volume>9</volume>
        <issue>3</issue>

 
    <startPage>1057</startPage>
    <endPage>1062</endPage>

	 
      <doi>10.13005/bpj/1048</doi>
        <publisherRecordId>11737</publisherRecordId>
    <documentType>article</documentType>
    <title language="eng">Virulence Factors Profile and Antimicrobial Resistance of Acinetobacter baumannii Strains Isolated from Various Infections Recovered from Immunosuppressive Patients</title>

    <authors>
	 


      <author>
       <name>Mohammad Darvishi</name>

 
		
	<affiliationId>1</affiliationId>
      </author>
    

	

	

	


	


	
    </authors>
    
	    <affiliationsList>
	    
		
		<affiliationName affiliationId="1">Infectious Diseases and Tropical Medicine Research Center (IDTMRC), AJA University of Medical Sciences, Tehran, Iran.</affiliationName>
    

		
		
		
		
		
	  </affiliationsList>






    <abstract language="eng">Natural inherent of <em>Acinetobacter baumanni</em> to survive in hard conditions in surfaces and its ability to resist against commonly used antibiotics in hospitals caused it to be one of the most prevalent cause of hospital infections. The present study was carried out to research the prevalence, antibiotic resistance pattern and distribution of virulence genes in the <em>A. baumannii</em> strains of various infections of immunosuppressive patients. One-hundred and fifty samples were collected and cultured. Their positive results were subjected to disk diffusion and PCR. Of all 150 samples studied, 20 samples (13.33%) were infected with <em>A. baumannii</em>. Wound infections had the highest prevalence of <em>A. baumannii</em> (16%). <em>Csga</em> (70%) and <em>cnf1</em> (50%) were the most commonly detected virulence genes.<em> A. baumannii</em> strains showed the highest levels of resistance against ampicillin (100%), tetracycline (95%), gentamycin (75%) and cephalexin (60%), while lowest against imipenem (5%) and ceftriaxone (35%). Statistically significant difference was seen between the type of samples and prevalence of <em>A. baumannii</em>, prevalence of antibiotic resistance and also distribution of virulence genes (<em>P</em> &lt; 0.05). Quick determination of infections caused by <em>A. baumanni</em> and its treatment with imipenem can decrease the risk of <em>A. baumanni</em>’s infections.</abstract>

    <fullTextUrl format="html">https://biomedpharmajournal.org/vol9no3/virulence-factors-profile-and-antimicrobial-resistance-of-acinetobacter-baumannii-strains-isolated-from-various-infections-recovered-from-immunosuppressive-patients/</fullTextUrl>

<keywords language="eng">

      
        <keyword>Acinetobacter baumanni</keyword>
      

      
        <keyword>Virulence genes</keyword>
      

      
        <keyword>Antibiotic resistance pattern</keyword>
      

      
        <keyword>Immunosuppressive patients</keyword>
      

      
        <keyword>Clinical infections</keyword>
      
</keywords>
  </record>
</records>