eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-12-22 9 3 967 975 10.13005/bpj/1036 11771 article Anna Viktorovna Kudryavtseva 1,2 Kirill Mikhailovich Nyushko 2 Andrew Rostislavovich Zaretsky 3,4 Dmitriy Alekseevich Shagin 3 Andrey Dmitrievitch Kaprin 2 Boris Yakovlevich Alekseev 2 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia. Pirogov Russian National Research Medical University, Moscow, Russia. Evrogen Lab LLC, Moscow, Russia. Clear cell renal cell carcinoma (ccRCC) is one of the most frequent urological malignancies with a high mortality rate. The search for genes that could be potential targets for therapy as well as diagnostic and prognostic markers is an important task. In this work the expression of nine genes, encoding nuclear retinoid receptors, in ccRCC was analyzed by bioinformatics and quantitative PCR methods. We have identified the upregulation of RARB, RARG, and RORC genes that encode RAR-beta, RAR-gamma, and ROR-gamma nuclear retinoid receptors, correspondingly. As is well known, all of them can bind trans-retinoic acid. It allows assuming that the nuclear retinoid receptors may play significant role in the alterations of retinoic acid metabolism in ccRCC and contribute to the diseases progression https://biomedpharmajournal.org/vol9no3/upregulation-of-rarb-rarg-and-rorc-genes-in-clear-cell-renal-cell-carcinoma/ clear cell renal cell carcinoma nuclear retinoid receptors gene expression quantitative PCR