eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-12-22 9 3 1009 1012 10.13005/bpj/1041 10760 article Siva Kumar Nadella 1 Raveendra Kumar N 2 Department of Pharmacology- Alluri Sitarama Raju Academy of Medical Sciences (ASRAM)-Eluru. Department of Pharmacology, Katuri Medical College-Guntur. A.P. This experimental study was undertaken to see the hepatoprotective activity of ethanol extract of Mangifera-indica dried leaves against CCl₄ induced acute liver damage on albino rats. CCl₄ (1ml/kg) significantly elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, Total bilirubin, Protein and depleted antioxidant enzymes GSH  upon administration of CCl₄ (1ml/kg) to albino rats. After treatment with MI leaf Extract (300mg/kg), MI leaf Extract (600mg/kg) for two weeks there is significantly reduced the elevated levels of biochemical markers mentioned above. These results suggest that this MI leaf Extract may have the potential therapeutic value in the treatment of CCl₄ induced hepatic damage and some liver diseases. Hepatoprotective activity of this extract may be attributed to the anti-oxidant principles in it. https://biomedpharmajournal.org/vol9no3/mangifera-indica-leaves-extract-effect-on-liver-function-in-experimental-animal-studies/ Antioxidant  MI leaf Extract  CCl₄  Liver damage Silymarin Hepatoprotective