eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-12-22 9 3 1219 1224 10.13005/bpj/1070 11098 article Sri Rahayu Santi 1 I Made Sukadana 1 Department of Chemistry-Faculty of Science and Maths. This study aimed to evidence the antiatherosclerosis of n-buthanol extract of gayam stem bark which were indicated through the decrease of 8-OHdG level and expression of ICAM-1 in Wistar rats that were treated with a high fat diet or hypercholesterolemia conditions within 4 months of observation. The study was initiated by preparing n-buthanol extract of gayam stem bark which was obtained from the partition of 95 g ethanol extract of gayam stem bark. A total of 30 g of n-buthanol concentrate extract was obtained and then was applied to Wistar rats for 4 months with the use of the posttest only control group design. Twenty-five Wistar rats were randomized into 5 groups, P₀ (negative control), P₁ (positive control, hypercholesterolemia), P₂ (hypercholesterolemia + n-buthanol extract in the dose of 50 mg/kg bw), P₃ (hypercholesterolemia + n-buthanol extract in the dose of 100 mg/kg bw), and P₄ (hypercholesterolemia + n-buthanol extract in the dose of 150 mg/kg bw). The results showed that n-buthanol extract of gayam stem bark in the dose of 100 mg/kg bw was able to decrease the levels of 8-OHdG, while in the dose of 100-150 mg/kg bw the extract could decrease the expression ICAM-1 endhotel aorta in wistar rats hypercholesterolemia. https://biomedpharmajournal.org/vol9no3/antiatherosclerosis-n-buthanol-extract-of-inocarpus-fagiferus-fosb-stem-bark-through-the-decrease-of-8-ohdg-level-and-expression-icam-1-in-rats-hypercholesterolemia/ Inocarpus fagiferus Fosb Antiatherosclerosis ICAM-1 8-OHdG Hypercholesterolemia