eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-08-21 9 2 555 561 10.13005/bpj/972 7675 article Mohsen Mohammadi 1 Mohammad Jafar Rezaie 2 Ayoob Rostamzadeh 3 Azra Allahveisi 2 Hamid Reza Mohammadi 4 Fatemeh Mohammadi 5 Hepatitis Research Centerand Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran . Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Anatomy and Neuroscience, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. Department of Toxicology and Pharmacology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Melatonin (MT) (N-acetyl-5-methoxytryptamine) is a lipophilic and hydrophilic indoleamine with various physiologic functions MT presents in all cells and tissues and distributes in all cell compartments. Liver is the only organ of circulating MT metabolism. The roles of MT in various liver pathologies have been extensively studied, and it is believed that oxidative stress (OS) and lipid peroxidation (LPO) are the key causing factors of almost all conditions compromising liver function, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), diabetes, liver fibrosis and cirrhosis. MT improves energy production and reduces apoptosis OS and LPO in liver. MT protects liver against OS through multiple ways: inhibition of inflammatory cytokines, direct scavenge of free radicals, stimulation of antioxidant enzymes, decrease of mitochondrial electron leakage and synergistic function with other classical antioxidants. https://biomedpharmajournal.org/vol9no2/signaling-pathways-of-melatonin-in-prevention-of-liver-disorders-via-suppressing-of-oxidative-stress-in-cellular-level/ Liver disease Melatonin Free radical Reactive oxygen species