eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-08-21 9 2 893 897 10.13005/bpj/1027 8173 article E. Rajesh 1 R. Jayasri Kurupaa 1 M. Kasthuri 1 N. Balachander 1 Dept of Oral Pathology, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai-600100 In oral tissues,the mast cell releases various pro-inflammatory cytokine tumor necrosis factor alpha (TNF-Ü) which stimulate leukocyte infiltration in various inflammatory condition of oral cavity such as oral lichen planus (OLP), periapical lesions, gingivitis & periodontitis. Mast cells are the local residents of the connective tissue and plays an important role in immunopathology and producing mitogenic cytokines.These cells plays a role in pathogenesis of oral diseases. https://biomedpharmajournal.org/vol9no2/role-of-mast-cell-in-oral-pathology/ tissues  releases  various