eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-08-21 9 2 859 862 10.13005/bpj/1018 8191 article M. K. Masthan 1 N. Anitha 1 S. Hari Priya 1 N. Aravindha Babu 1 Department of Oral Pathology, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai – 600100. In 1868, Paul Langerhans first described langerhans cell, they are dendritically shaped cells, which were located in epidermis of the squamous epithelia. Langerhans cells are seen in all suprabasal layer of stratified squamous epithelium. They play a vital role in local defense mechanisms in the epithelium. They are bone marrow derived dendritic cell and act as antigen presenting cells (APCs) of immune responses. APCs, the lymphocytes respond to specific microbes. In this article we have reviewed the physiology and mechanism of action of their role in different pathological conditions. https://biomedpharmajournal.org/vol9no2/langerhans-cells-pathophysiology-an-overview/ Langerhans  immunological  stratum corneum