eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2016-04-28 9 1 365 375 10.13005/bpj/948 6576 article Lucy Mohapatra 1 Subrat Kumar Bhattamisra 2,4 Rama Chandra Panigrahy 1 Sambit Kumar Parida 3 SRF-CSIR; Berhampur University, Berhampur, Odisha, India. Dept. of Pharmacology, Roland Institute of Pharm. Sciences, Berhampur, Odisha, India. Dept. of Pharmaceutical chemistry, College of Pharm. Sciences, Berhampur, Odisha, India. Present address: Dept. of Life Sciences, School of Pharmacy, International Medical University, BukitJalil 57000, Kuala Lumpur, Malaysia. Seaweeds have proved to be exceptional resources of nutrients and secondary metabolites. The present study was designed to evaluate the antioxidant, hypoglycaemic and antidiabetic activities of some seaweeds of east coast of India namely Gracilariaverrucosa, Enteromorphacompressa, Ulvafasciata and Turbinariaconoides. Petroleum ether, ethyl acetate and methanol extracts of these seaweeds were evaluated for antioxidant activity by means ofassays like total phenolic content, total reducing power, Nitric Oxideand H₂O₂scavenging tests.The extracts with superior antioxidant activity among these seaweeds were further tested forhypoglycaemic and antidiabetic activity. Ethyl acetate extract of Ulva fasciata(EAU) has shown promising results after all these tests. IC₅₀ value of EAU was found to be 123.39 and 127.65μg/ml for H₂O₂and NO free radical scavenging activityrespectively. Total phenol content for EAU was 207.23 ± 2.41mg/g. Fasting plasma glucose level in normal mice was significantly (p<0.05) decreased even after 6 days of EAU treatment at the dose 200mg/kg. The area under curve of oral glucose tolerance test was not affected significantly, though considerable reduction in AUC was found in both EAU 100 and 200 mg/kg treated groups. It was found that EAU has potent in vitro alpha-amylase inhibiting property when compared to the standard, Acarbose. The current findings suggest that,the anti-diabetic activity of U.fasciatamay be due to its underlying antioxidant, hypoglycemic and alpha amylase inhibiting property. Hence, this seaweed can be beneficial for diabetic individuals. https://biomedpharmajournal.org/vol9no1/evaluation-of-the-antioxidant-hypoglycaemic-and-anti-diabetic-activities-of-some-seaweed-collected-from-the-east-coast-of-india/ Alloxan Antioxidants Plasmaglucose Oral glucose tolerance test Phenolic Plasma triglyceride Plasma total cholesterol