eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 691 694 10.13005/bpj/769 4333 article Aravindhan T Ranganathan 1 Bagavad Gita 2 V. Ramya 2 Department of Periodontics, Tagore Dental College, Rathinamangalam, Chennai, India. Department of Periodontics, Sree Balaji Dental College and Hospital, Bharath University, Chennai-60010, India. Periodontal diseases are polymicrobial diseases resulting in inflammation of the supporting structures of the teeth. The removal of the plaque biofilm by mechanical therapy not always results in total resolution of the lesion. Frequently adjuvant administration of antibiotics is required for better results. This article overview the factors to be considered while administering systemic antibiotics as an adjunct to mechanical debridement. https://biomedpharmajournal.org/vol8octoberspledition/role-of-systemic-antibiotics-in-the-management-of-periodontal-diseases/ periodontitis Systemic antibiotics Amoxicillin