eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 61 67 10.13005/bpj/652 4252 article N. Balaji 1 G. S. Asokan 1 V. Anand 1 S. Aswini 1 E. Rajesh 2 Tagore Dental College and Hospital, Ratinamangalam, Vandalur post, Tamilnadu, India. Sree Balaji Dental College and Hospital, Bharath University , Chennai. Mucormycosis is a life threatening fungal infection caused by fungi of the order Mucorales and is one of the fulminant and fatal opportunistic infections, characterized by very acute onset, with a high mortality rate. Rhinocerebralmucormycosis is the most common type and its extension to the orbit and brain is quite usual. It is commonly reported in immunocompromised patients such as poorly controlled diabetics, immunosuppression with corticosteroids, hematological malignancy, solid malignancy, iron overload and burns. Mucormycosis is on the rise with an increase in incidence of Diabetes mellitus and HIV infection leading to immunocompromised status of the patient. Here in, reporting two cases of rhinocerebralmucormycosis in two diabetic patients with  palatal perforation in  both cases and this is a rare and late occurrence. One was in a known systemic lupus erythematosus (SLE) patient, which is a very rare incidence.   Both the patients were successfully treated with a combination of surgical debridement and systemic amphotericin B administration. By presenting these two case reports we would like to point out that mucormycosis should be included in the differential diagnosis of hard palate ulcers and cellulitis, especially in diabetic patients. https://biomedpharmajournal.org/vol8octoberspledition/rhino-orbital-mucormycosis-presenting-as-palatal-ulcers-a-report-of-two-cases/ Mucorales  rhino orbital subtotal maxillectomy vascular thrombosis