eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 121 125 10.13005/bpj/662 4263 article P. Sai Krishna 1 K. A Shankar 1 N. Balachander 2 Tagore dental college and Hospital, Chennai, Tamilnadu, India. Sree Balaji Dental College Hospital, Bharath University, Chennai. Orthokeratinized odontogenic cysts(OOC’s) are relatively uncommon developmental cysts lined with orthokeratinized epithelium consisting of prominent granular layer and a basal layer of low cuboidal flattened cells that show no tendency for nuclear palisading. OOC’s has been considered a distinct entity from odontogenic keratocyst since they exhibit a less aggressive behavior and a very low recurrence rate. This report describes a 27 year old female patient who presented with a cyst with unique histopathological features. The purpose of this article is to present a case of OOC in the posterior mandible and also emphasize on the need for differentiating it from keratocystic odontogenic tumor(KCOT) with a comprehensive literature review. https://biomedpharmajournal.org/vol8octoberspledition/orthokeratinized-odontogenic-cyst-of-the-mandible-case-report-with-unusual-histopathologic-features-with-review/ odontogenic cyst orthokeratinizedodontogenic cyst keratocysticodontogenic tumor