eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 09 13 10.13005/bpj/644 4208 article Jai Santhosh Manikandan veerasamy 1 L. S Makesh raj 1 S Leena Sankari 2 Anitha 2 Tagore Dental College and Hospital, Rathinamangalam, Chennai Department Of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath University , Chennai. Massive osteolysis is a rare condition of unknown aetiology resulting in progressive destruction of bony structures. Literature reviews suggest less than 40 cases of massive osteolysis in the jaws has been reported.Clinically it is seen mostly between age groupof 18-40 years and depending on the site of involvement is shows various clinical presentation. Even after so many advances in the field of medicine still this disease is still considered as nightmare for the pathologist as the course of the diseaseand prognosis after treatment are unpredictable. As its name indicates its radiological features varies from slow resorption of affected bone finally resulting in complete loss of affected bone.No specific treatment is proven effective against this disease. Hence the purpose of this review is to provide comprehensive in depth idea about the disease to help in early diagnosis. https://biomedpharmajournal.org/vol8octoberspledition/massive-osteolysis-of-oral-cavity-a-review-with-emphysis-on-its-etio-pathogenesis-and-histological-appearance/ massive osteolysis bone disease vanishing bone disease