eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 767 772 10.13005/bpj/781 4373 article Chronic rhinosinusitis with polyposis is a clinical condition that has been poorly understood and difficult to treat. Its features are the inflammation of nasal and paranasal mucosa with polyp. The aim of this study was to determine variant histopathology in these patients and its outcome based on postoperative symptoms and endoscopic findings. Ninety three patients with chronic polypoid sinusitis with no previous history of sinus surgery and any other diseases underwent endoscopic surgery. Histological samples of polyp were analyzed. The samples were classified samples into 4 groups based on the Hellquist classification: Allergic (A), chronic inflammatory (B), seromucinous (C), and polyp with atypical stroma (D).Patients were followed by clinical symptoms and endoscopic assessments for 12 months. Age, smoking behavior, family history, allergy, asthma, and sensitivity to Aspirin were assessed. In addition, histological types of polyps were investigated and recurrent polyps were determined. The group A had highest frequency 71% (66 cases), followed by the group B 20.4% (19 cases) and C 8.4% (8 cases). Twenty percent of patients (27 cases from the group A) had recurrent polyp. Recurrence had a significant relation with type of pathology and history of asthma and allergy. Recurrence in the group A was statistically significant (P-value=0.0036) compared with the two other groups. This study showed that allergic polyp was the most frequent polyp and recurrent in patients with chronic polypoid rhinosinusitis. In addition, there is a relation between type of pathology and history of asthma and allergy with recurrence after surgery. https://biomedpharmajournal.org/vol8octoberspledition/histopathological-variants-of-chronic-polypoid-rhinosinusitis-and-clinical-outcomes/ Chronic polypoid rhinosinusitis Histopathology Clinical outcome