eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-10-25 8 October Spl Edition 133 138 10.13005/bpj/664 4264 article V.Vignesh 1 N. Aravindha Babu 2 N. Balachander 2 L. Malathi 2 Tagore dental college and hospital. Department of Oral Pathology and Microbiology(COCPAR), Sree Balaji Dental College and Hospital, Bharath University , Chennai. Teeth form as epithelial appendages such as hairs and glands. During development, reciprocal and sequential epithelial-mesenchymal interactions regulate processes such as proliferation, differentiation and morphogenesis. These interactions are mediated by conserved signaling pathways that are reiteratively used during development of all organs. Mutations in genes encoding molecules in the signaling pathways cause numerous abnormalities in craniofacial bones and teeth including missing or supernumerary teeth, and disturbances in formation of dentin and enamel. This article is regarding the genetic basis of tooth development, methods used to study it, and the genes that have been definitively implicated in the development of human dentition and the brief notice on the deformities caused due to the mutation of the these genes. https://biomedpharmajournal.org/vol8octoberspledition/genes-in-tooth-development/ Homeoboxgenes (Hox) MSX DLX PAX