eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-12-28 8 2 1315 1322 10.13005/bpj/892 6047 article Seyed Mohamad Hoseini 1 Hodjatolah Shahbazian 2 Zohre Moheb Al Aba 3 Department of Radiation and oncology of Gholestan University Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Kidney Transplant Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Breast cancer is one of the most common cancers among women. Estrogen and progesterone receptors status plays an important role in determining disease prognosis and choosing appropriate type of treatment for this disorder. Therefore, this study aimed to investigate the prevalence of estrogen and progesterone receptors in patients with breast cancer. This is a retrospective and descriptive study conducted on the medical records of 3593 patients with breast cancer referred to the radiotherapy and oncology department of Ahvaz Golestan Hospital during the years of 2001-2011. The relevant data were reviewed and information such as ER, PR, HER2, age, gender and cancer grade were extracted for further evaluation. Among the 3593 cases, hormone receptor status was determined in 2019 cases that among these, 1331 patients (66%) had positive ER and 1209 (60%) had positive PR. Hormone receptors connection with age of menopause was like this way that the number of positive ER (in age of premenopausal) was 1110 patients (64%) and in ages after menopause was seen in 203 patients (76%), respectively. Positive PR before menopause was also in 1010 patients (56%) and after menopause was in 182 patients (68%) (P: 0.0001). In patients with grades 2 and 1 the positive ER frequency is more than grade 3 (72% in Grade 1 and 2 and 55% in grade 3) (P: 0.000) among all types of HER2, HER2 + 3 frequency was higher in the patients (43%). The Luminal A amount (PR + ER +, HER2-) was 23% and B Luminal (ER +, PR +, HER2 +) was 19% and Triple negative (- HER2, ER-PR-) was 10% of HER2 + (ER-PR-HER2 +) was 18 percent. The hormone receptors frequency in Khuzestan patients is similar to their frequency in Saudi Arabia and European countries and white Americans patients and is more than its frequency in India, African-American and Tanzania patients. Triple negative incidence form in Khuzestan patients is also less than the region countries (Saudi Arabia and India), and is similar to the European countries statistics (Germany and Italy). https://biomedpharmajournal.org/vol8no2/the-relative-distribution-frequency-of-hormonal-factors-estrogen-and-progesterone-receptors-in-patients-with-breast-cancer-referred-to-ahvaz-golestan-hospital-during-2001-2011/ Breast cancer estrogen Receptor progesterone receptor