Talaeizadeh A, Shahbazian H, Abaspur S. Prevalence of Colorectal Cancer Recurrence in Patients Undergoing Surgical Procedures in Educational Hospitals Affiliated with Ahvaz Jundishapur University of Medical Sciences During 1997-2007. Biomed Pharmacol J 2015;8(2)

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Abdolhassan Talaeizadeh^1*, Heshmatollah Shahbazian² and Somaye Abaspur³  

¹School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ²Department of Kidney Transplant Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ³School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI : https://dx.doi.org/10.13005/bpj/889

Abstract

Colorectal cancer has been shown to be the second main reason for the deaths of cancer. 20 to 40 percent of the patients suffering from the disease recurrence have the salvage surgery. In this study we investigate the rate and the process of the colorectal cancer recurrence on the patients who are put under surgery. This study is a retrospective research based on available data. The records of 207 patients with colorectal cancer, who had been put under surgery operation in the hospitals of Ahvaz Jundishapur University of Medical Sciences from the early 1997 to 2007 were examined, the available variables were studied and the collected data were statistically analyzed. Of the 207 patients examined, 92 patients (%44.5) had recurrent cancer. Among the 92 patients with recurrent cancer, 53 patients (%57.6) were females and 39 patients (%42.4) were males, showing that the recurrence ratio in both genders had no significant difference (p-value= 0.43). 47 patients (%51.1) had colon cancer and 45 cases (%48.9) were suffering from rectal cancer, showing that the ratio of cancer recurrence in both diseases had no significant difference (P-value= 0.59). 33 patients (%36) were in stage II and 59 cases (%64) were in stage III, and it was observed that there is a significant difference between the recurrence rate in stage III and that in stage II (P-Value-= 0.04). Adjuvant therapy in rectal cancer reduces recurrence to such a large extent that there was a significant difference between those who had received this therapy type and those who had not (P-value= 0.001). However, no significant difference was observed between the two groups of patients with colon cancer who had and had not received Adjuvant therapy (Pvalue= 0.07). Being in a more developed stage of disease increases the rate of cancer recurrence and the most common organ for recurrence was the metastasis to the liver. In this study, adjuvant therapy decreases recurrence of the rectal cancer, but not that of the colon cancer

Keywords

Colorectal cancer; Surgery; Radiotherapy; Chemotherapy; Recurrence