eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-12-28 8 2 937 943 10.13005/bpj/845 3908 article Ehsan Barati 1 Sara Soleimani Asl 2 Seyed Ali Pourbakhsh 3 Mahmoud Jamshidian 3 Siamak Shahidi 4 Student of Veterinary Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Department of Microbiology ,Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Alzheimer’s disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the investigating effect of Borago officinale on hipocampla IL-1 Beta protein in the Beta Amyloid peptid induced of inflammation in the rat. Wistar male rats received intrahippocampal (IHP) injection of the Aβ(25–35) and borage extract throughout gestation (100 mg/kg).inflamation was confitmed by pathologist.for mesearing the expression of the IL-1 Beta gene we used RT- PCR method and for extraction of the IL-1 Beta protein we used western bloting method.result showed that using Borago officinale lead to reduce IL-1 Beta gene and protein. This data suggests that borage could improve the reduction of inflammation factors such as IL-1 Beta and borage consumption may lead to an improvement of AD-induced cognitive dysfunction. https://biomedpharmajournal.org/vol8no2/investigating-the-effect-of-borago-officnale-on-hipocampal-il-1-beta-protein-and-gene-in-the-amyloid-%ce%b2-peptide-25-35-induced-of-inflammation-in-rat-2/ IL1-Beta Alzheimer RT-PCR Western Blot Amyloid β-Peptide