eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-12-28 8 2 725 729 10.13005/bpj/819 3737 article V. Shankarram 1 M.D.S. Lakshmi Narayanan 2 M.D.S. Uma Sudhakar 3 M.D.S. Joyson Moses 3 M.D.S. Tamil Selvan 4 M.D.S. S. Parthiban 1 Department of periodontics., Thai moogambigai dental college, Chennai.600107 MOBILE 9444071251,994071251. Department of endodontics., Thai moogambigai dental college, Golden George nagar, Chennai 600107. Department of periodontics., Thai moogambigai dental college, Golden George nagar, Chennai 600107. Department of Oralpathology., Sree Ramachandra Dental College. Chennai. The oral cavity is an entry of other systems of the body; it should not be viewed as an isolated area. Diseases that it lays down can have systemic scope and significantly affect the quality of life of  individuals who suffer them. Periodontal disease is one of the oral health problems that most often affect the global population, lack of treatment leads to loss of tooth organs and consequently alters the digestion and nutrition, without considering other relevant aspects as phonation, aesthetics and social or emotional impact. The importance of periodontal disease has raised possible bidirectional relationships with systemic diseases such as diabetes, metabolic syndrome and cardiovascular disease. We address herein the role of oxidative stress in the pathogenicity of periodontal disease. In the same context, another disease that has become relevant in our days is the oral cancer .Detection of the reactive oxygen species in the periodontitis patients  and oral cancer patients reveal the relationship between the oxidative stress in periodontitis and oral cancer patients https://biomedpharmajournal.org/vol8no2/detection-of-oxidative-stress-in-periodontal-disease-and-oral-cancer/ Detection   cavity  systems  periodontitis