eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-06-18 8 1 291 299 10.13005/bpj/611 839 article Farokhnia Farzaneh 1 Hosseini Seyed Ebrahim 1 Vahdati Akbar 1 Department of Biology, Science and Research Branch, Islamic Azad University, Fars, Iran. azathioprine is a chemical drug that is used for treatment of diseases with immunological origin. Studies have proven that the drug has potential side effects on the renal tissues. So finding a suitable antioxidant to reduce the pathological effects of azathioprine drug on kidney is the objective of the present study. Methods: the study was conducted on 42 mature female rats. After weighing, the rats were divided into 6 groups of 7 each, which includes control (without any treatment), blank (received 5 mg ofnormal saline), experimental group1 (azathioprine (50mg/kg) were administered intraperitoneally), experimental group2 (received azathioprine (50mg/kg) intraperitoneally and orally received wormwood extract (125mg/kg)), experimental group3 (received azathioprine (50mg/kg) intraperitoneally and orally received wormwood extract (250mg/kg)), experimental group4 (received azathioprine (50mg/kg) intraperitoneally and orally received wormwood extract (500mg/kg)). After 28 days, the rats of all groups became unconscious and their renal tissues were isolated for histological studies. Results: the results showed that reduction of glomerular and collecting ducts diameter, as well as malpighian body diameter were observed at the level of 5% in the experimental group1 in compared to control. The collecting ducts diameter in the experimental group3,which had received the maximum dose of the extract,increased compared to the experimental group 1. Conclusion: the obtained results of the study show that azathioprine drug causes impairment in renal tissues and wormwood extract due to its antioxidant properties, reduces the pathological effects of azathioprine. https://biomedpharmajournal.org/vol8no1/investigating-on-effect-of-wormwood-extract-on-reduction-of-renal-toxicity-in-treated-rats-by-azathioprine/ Wormwood Histopathologic Kidney Azathioprine Rat