eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-06-18 8 1 27 33 10.13005/bpj/578 782 article Djanggan Sargowo 1,4 Indra Prasetya 1 Ria Ashriyah 1 Ira Setyawati 1 W Titin Andri 2 Teuku Heriansyah 3 Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University / Dr. Saiful Anwar Hospital, Malang Department of Nursery, Faculty of Medicine, Brawijaya University, Malang Department of Cardiology and Vascular Medicine, Faculty of Medicine, Syiah Kuala University / Dr. Zainoel Abidin Hospital, Banda Aceh Department of Internal Medicine, Faculty of Medicine, Brawijaya University / Dr. Saiful Anwar Hospital, Malang. Jaksa Agung Suprapto Street, no. 2, Malang 65111, Indonesia This study was aimed to evaluate anti-inflammatory and antioxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerosis. The atherosclerotic rats were randomly divided into four groups (5 rats each group) : atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6 , IL - 10, hsCRP, TNF - α, lipid profile and foam cell. After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease significantly. PsP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) descriptively at PsP doses 150 mg/kgBW. While the levels of TNF-α (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profile by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of atherogenesis significantly decreased by administration of PsP. PSP can be useful to reduce inflammatory processes and oxidative stress to prevent atherogenesis . https://biomedpharmajournal.org/vol8no1/anti-inflammation-and-anti-oxidant-effect-of-active-agent-polysaccharide-peptide-ganoderma-lucidum-in-preventing-atherosclerotic-diseases-2/ polysaccharide peptide (Ganoderma lucidum) anti-inflammation anti oxidant cardiovascular disease atherosclerosis