eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-03-15 8 March Spl Edition 73 77 2366 article Soheila Nikakhlagh 1 Ansyeh Bakhshi 2 Zohreh Noroozi 3 Associated professor of otolaryngology, Head and neck surgery, Hearing and Speech Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Medical Student ,Hearing and Speech Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Resident of otolaryngology, Head and neck surgery, Hearing and Speech Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Chronic rhinosinusitis is a multi-factorial disease can significantly affect the patients' life,. Along with several medicinal and surgical treatments, advancement of endoscopic surgery, in the last three decades, has led to acceptable results in the improvement of the treatment of these patients. This study aims for analyzing the effect of endoscopic sinus surgery on the quality of life (QoL) of patients with chronic rhinosinusitis, using SNOT-20 questionnaire This is a prospective analytical epidemiological study conducted on 44 patients diagnosed with chronic rhinosinusitis underwent functional endoscopic sinus surgery (FESS) were included.  Demographic data including age, gender, clinical symptoms, and type of rhinosinusitis were obtained, using SNOT-20 questionnaire, before and six months after the surgery. Then, the findings were compared to each other to investigate the effect of endoscopic surgery on the quality of life of the patients.  In addition, findings of endoscopic surveillance and CT-scan were recorded before and six months after the surgery, based on Kennedy and Lund-Mackay classification.  Descriptive statistics were used to calculate the mean and standard deviation of the data. Moreover, paired t-test was used for comparing the scores of the quality of life before and after the surgery. The study sample included 28 men (62.2%) and 17 women (37.8%), who received a six month follow-up. The mean age of the patients was 39 years. Based on SNOT-20, the mean score of the quality of life improvement was 67.26 before the surgery. In addition, the post-surgery mean of overall score was 4.82. Patients obtained the improvement score of 21.84, on average, in SNOT-20, indicating a statistically significant improvement in SNOT-20 (p<0.0000001). The greatest improvement was achieved in nasal and facial congestion.    The mean score of CT-scan was 19.65 and 8.10, before and after the surgery, respectively, indicating a statistically significant improvement (p=0.000000536). There was not any statistically significant difference in the score of endoscopic findings after performing FESS (p=0.6137). Endoscopic sinus surgery significantly improved the symptoms of patients with chronic rhinosinusitis, reducing the need for antibiotics and antihistamines. We concluded that subjective results were more significant than CT-scan and endoscopic surveillance findings, after the surgery. https://biomedpharmajournal.org/vol8marchspledition/evaluation-of-quality-of-life-of-patients-with-chronic-rhinosinusitis-before-and-after-endoscopic-sinus-surgery/ Chronic Rhinosinusitis Quality of Life Endoscopic Sinus Surgery SNOT-20