eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-05-02 7 1 369 373 10.13005/bpj/500 2998 article Pourahmadi Mohammad 1 Golami Liela 2 Farzam Mohsen 3 Kargar Jahromi Hossein 4 Department of Anatomy, Jahrom University of Medical Science, Jahrom, Iran Department of General of Fars Province Education , Jahrom ,fars , Iran Department of Physiology, Veterinary School, Kazerun Branch, Islamic Azad University, Kazerun, Iran. Zoonoses research center, Jahrom University of Medical Sciences, Jahrom, Iran. Cinnamon with scientific name of Cinnamomum Zeylanicum Nees and common name of Cinnamon is aromatic and pleasant plant. The treatment plant has anti spasmodic, carminative, anti-diarrhea, anti-bacterial, anti-parasitic, and cooling effects. Due to the possible side effects of Co-codamol on the body and cinnamon benefits, the current study seeks to investigate the possible effects of cinnamon on Co-codamol complications. 42 female Wistar rats were randomly divided into 7 groups. The first group (control group) did not receive any medication. Experimental group 1 received a dose of 50 mg / kg cinnamon, experimental group 2 received, 200 mg / kg cinnamon, experimental group 3 received, 400 mg / kg Co-codamol alone, experimental groups 4 and 5; in addition Co-codamol medicine received 50 mg / kg and 400 mg / kg cinnamon intraperitoneally. At the end of 21 days, blood samples were prepared from the rats and the LH and FSH serum concentrations were measured by ELISA. The data is then tested by ANOVA (One-way analysis of variance) at a significance level (P<0.05) using SPSS software version 18. Experimental results show that the concentrations of LH in the experimental group received 50 mg/kg cinnamon has a significant increase compared to controls. Concentrations of FSH in the experimental group who received a dose of 50 mg/kg cinnamon have a significant increase compared to the control group (P< 0.05). : The results suggest that cinnamon extract in a dose-dependent manner with its antioxidant properties reduces the side effects of Co-codamol medicine on Gonadotropins hormones. https://biomedpharmajournal.org/vol7no1/the-effect-of-hydro-alcoholic-cinnamon-extract-on-changes-of-gonadotropins-lh-and-fsh-in-mice-treated-with-co-codamol/ Cinnamon Co-codamol LH FSH rat