eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-05-02 7 1 121 124 10.13005/bpj/460 2866 article Padera Faryadyan 1 Afra Khosravi 2 Sara Faryadian 3 Meysam Kashiri 4 Reza Valizadeh 5 Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, Iran. Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences. Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, Iran. Department of Hematology, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. Department of Psychology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Ziziphora persica dried leaves are used in Iranian traditional medicine as an anxiolytic and mood enhancer, but its contributory mechanisms are unknown. In this research, efficacy of aqueous extract of this plant was investigated on depressedmale rats measuring changes in levels of CSF serotonin and dopamine as mood indicators. Four groups of male Wistar rats, seven rats in each, were enrolled in this study.Swimming test was used to assure that depression was induced by injection intrapritonal of reserpine (5mg/kg). After 14 days oral intake of plant aqueous extract of plant (2mg/10ml), CSF serotonin and dopamine levels of rats were measured using ELISA Kit. Our finding indicated that aqueous extract of Ziziphora persica significantly increased concentration of CSF serotonin and dopamine in depressed group who were treated by this plant. Concentration of CSF serotonin in control group receiving extract was increased as compared to the control group ww wwww ho didn’t receive any medicine. These results showed serious changes of neurotransmitters due to Ziziphora persica which can be translated as mood enhancer. It can be concluded that Ziziphora persica induces positive mood in depressive and control groups. https://biomedpharmajournal.org/vol7no1/the-aqueous-extract-of-ziziphora-persica-cause-positive-mood-on-depressive-rat/ Ziziphora persica Depression Serotonin Dopamine ELISA Rat