eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-05-02 7 1 75 80 10.13005/bpj/454 2848 article Om Prakash 1 S. A. Iqbal 2 Department of Chemistry, Saifia Science College, Barkatullah University, Bhopal - 462001, India. Crescent College of Technology Nabi Bagh, Karond, Bhopal - 462038, India. The present study deals with the synthesis and hypoglycemic activity of Fe(II) and Zn(II) complexes with Pioglitazone hydrochloride a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complexes are ionic and L2M (ligand-metal ratio) type which is further confirmed by Job’s method of continuous variation as modified by Turner and Anderson. Analytical data and elemental analyses agree with the molecular formulae of complexes viz. [(C19H19N2O3S)+2 Fe(OH2)2]SO42- and [(C19H19N2O3S)2 Zn]2Cl- and geometry of complexes are assigned as octahedral and tetrahedral.The ligand and metal complexes have been tested on wistar albino rats in order to assess their hypoglycemic activity and found that metal complexes are more potent than parent drug. https://biomedpharmajournal.org/vol7no1/hypoglycemic-study-of-feii-and-znii-complexes-of-pioglitazone-hydrochloride-on-wistar-albino-rats-using-alloxan-induced-method/ Pioglitazone synthesis complexes hypoglycemic activity alloxan method