eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-05-02 7 1 277 280 10.13005/bpj/487 2956 article Tripti Saxena 1 Anita Arya 2 Anuradha Jain Rathore 1 Nikhil Rajak 1 Sabiha Naz 1 Rakesh Shah 1 Department of Medical Biochemistry, Gandhi Medical College, Bhopal, India. Department of Medicine, Gandhi Medical College, Bhopal, India. Nonalcoholic fatty liver (NAFLD) in one of the major cause of fatty liver, occurring when fat is deposited (steatosis) in the liver not due to excessive alcohol. It is related to insulin resistance and the metabolic syndrome. Nonalcoholic steotohepatitis (NASH) is the most extreme form of NAFLD and is regarded as a major cause of the liver damage. Study has been carried out in 50 patients suffering from nonalcoholic fatty liver disease age groups of 20-60 years compared to 50 age and sex matched control. Mostly the age group of 40-50 years of cases is found significant as compared to control group of 40-50years. Biochemical parameters estimated were SGPT AND GGT. SGPT was found significantly( p<0.0001) increased(60.75±8.85) in cases as compared to control group (27.71±6.87) and GGT was found to be significantly(p<0.001) decreased (20.71±6.07) as compared to control group (21.90±8.44) This data suggests that the elevation of enzymes can be a particular and specific marker of nonalcoholic fatty liver disease but the value of GGT is not significant marker however detailed studies with large sample size may be required to establish liver enzymes as marker of nonalcoholic fatty liver disease. https://biomedpharmajournal.org/vol7no1/ggt-and-sgpt-a-rising-marker-in-diagnosis-of-non-alcoholic-fatty-liver-disease/ NAFLD (non alcoholic fatty liver disease) NASH (Nonalcoholic steatohepatitis) GGT (Gamma glutamyltransferase) MS (Metabolic syndrome)