eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-05-02 7 1 137 142 10.13005/bpj/463 2875 article Sara Faryadian 1 Amin Sydmohammadi 2 Afra Khosravi 3 Meysam Kashiri 4 Padera Faryadayn 4 Naser Abasi 5 Department Faculty of Medicine, Physiology, Ilam University of Medical Sciences . Ilam University of Medical Sciences . Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences. Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, Iran. Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Based on a traditional belief, Echium amoenum (Boraginaceae) dried flowers are used in Iran as an anxiolytic remedy and also as a mood enhancer. But interfering mechanisms unknown, In this study, efficacy of an aqueous extract of E.amoenum in depressive rat was evaluated, using measurement the changes level CSF serotonin and dopamine as indicator mood. Four groups of male wistar rats each group of seven rats were enrolled in this study. Depressive induced with intraperitoneal injection of reserpine (5mg/kg) and assessment depression by swimming test, the next two weeks of oral performing aqueous extract Echium amoenum, CSF serotonin and dopamine concentration of rats were measured using ELISA kit. Our finding indicated, performing aqueous extract Echium amoenum increased CSF serotonin and dopamine concentration in depression rats. The level of CSF serotonin enhanced in control group receiving Echium amoenum compared control group alone. These results showed the serious changes of neurotransmitters due to Echium amoenum which can be translated as mood enhancer. It can be concluded, Echium amoenum induce antidepressant effective in part by increasing level CSF serotonin and dopamine. https://biomedpharmajournal.org/vol7no1/aqueous-extract-of-echium-amoenum-elevate-csf-serotonin-and-dopamine-level-in-depression-rat/ Echium amoenum Depression Serotonin Dopamine GABA