eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-04-28 6 2 447 452 10.13005/bpj/441 2803 article Lincy Sara Varghese 1 Merin Ann Ninan 2 Neena Alex 2 Swetha Soman 2 Simi Jacob 2 Department of Microbiology, Bishop Kurialacherry College for Women, Amalagiri, Kottayam, India Department of Botany, Bishop Kurialacherry College for Women, Amalagiri, Kottayam, India. Emblica officinalis Gaertn. is the most celebrated plant in the Indian traditional system of unani and ayurvedic medicine. The present study was carried out to assess quantitatively, the in vitro antibacterial activity of aqueous, ethanolic and acetone extracts of fruits of Emblica officinalis against gram positive versus gram negative bacteria employing Staphylococcus aureus and E. coli, respectively. All the extracts exhibited significant antibacterial activity, more against S. aureus than E. coli. Among the extracts, acetone extract maximally inhibited the growth of S. aureus and E. coli at minimum concentration of the extract (0.1 µg and 1.0 µg, respectively). MIC for ethanol and aqueous extracts were 0.3 and 1.0 µg and 1.5 and 6.0 µg, respectively, for S. aureus and E. coli. It is concluded from the present study that E. officinalis is more inhibitory to gram positive than the gram negative bacteria. https://biomedpharmajournal.org/vol6no2/comparative-antibacterial-activity-of-fruit-extracts-of-emblica-officinalis-gaertn-against-gram-positive-versus-gram-negative-bacteria/ Emblica officinalis antibacterial assay well diffusion fruit extract S. aureu E. coli