eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-04-26 5 2 247 250 2487 article Reza Kazemi Darsanaki 1 Mahdiyeh Laleh Rokhi 2 Mahya Mohammadi 3 Golnaz Raeisi 3 Maryam Nourbakhsh 3 Morteza Azizollahi Aliabadi 3 Young Researchers Club, Lahijan Branch, Islamic Azad University, Lahijan, Iran. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Falavarjan, Iran . Department of Microbiology, Faculty of Basic Science, Lahijan Branch, Islamic Azad University, Lahijan, Iran. Natural Products, especially plants, have been used for the treatment of various diseases for thousands of years. Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Nettle (Urtica dioica L.) is widely grown in different parts of the world and has been used to promote health. In this study, aqueous extract of nettle leaf (Urtica dioica L.) was studied for antimutagenic properties against sodium azide and acrylic amide by Ames test in presence and absence of rat microsomal liver enzyme (S9). The results showed that nettle leaf aqueous extracts can inhibit mutagenic agents of sodium azide and acrylic amide. Nettle leaf aqueous extracts with the inhibition of 40.39% sodium azide and 43.34%, acrylic amide showed high potential in decreasing mutagenic agents. Antimutagenic activity was increased significantly when there were liver microsome extract (S9). https://biomedpharmajournal.org/vol5no2/antimutagenic-properties-of-nettle-leaf-aqueous-extract-urtica-dioica-l/ Nettle leaf Ames test Antimutagenic activity