eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-03-26 3 2 345 348 1568 article Habibeh Zare 1 Sasan Mohsenzade 2 F. Mobaien 3 Department of Biology, Payame Noor University, Busher Iran. Department of Biology, Shiraz University Iran. Bushehr Medical University Iran. Introduction Two important dangerous factors of atrosclerose disease are diabetes mellitus and cholesterolemia . from the old time garlic was was used and several studies were accomplished about the effects of garlic on decreasing blood sugar and blood cholesterol that some of them proved this subject and some of them. rejected that the objective of this research in the study of the effect of allium sativum consumption on some of blood biochemical factors in persons with high cholesterol and diabetes. Method This clinical study was accomplished on 25 persons with necessary qualifications and with more than 126 mg in deciliter blood sugar and 245 mg/dl blood cholesterol . each volunteer used 5 gr allium sativum twice in a day for 42 days and then did not use allium sativum at all for 42 days .3 stages of phlebotomy was done as fasting in order to measuring the biochemical factors. The results were analyzed by using ANOVA test and p<0.05 was considered meaningful. Results The average amount of fasting blood sugar (p<0.01) and total cholesterol (p<0.001) after 42 days allium sativum consumption decreased meaningfully. But after stopping allium sativum consumption it increased again.HDL-C increased meaningfully HbALC decreased(p<0.05).allium sativum consumption did not show meaningful effect on ceratinin urine of uric acid of cholesterol liver function tests with low. Conclusion With regard to current research results, it can be concluded that allium sativum consumption can decrease total cholesterol of blood ,FBS and HbALC and can increase HDL-C so garlic can be useful in light diabetes mellitus and hyper lipidemic especially in persons that can not bear chemical medicines. https://biomedpharmajournal.org/vol3no2/the-effect-of-allium-sativum-on-blood-biochemical-factors-in-people-with-high-blood-cholesterol-and-diabetes/ Hyper lipidemic blood sugar increasing