eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-03-26 3 2 425 429 1640 article Alok K. Pareek 1 P. E. Joseph 1 Daya S. Seth 1 School of Chemical Sciences, Department of Chemistry, ST. John’s College, Agra- 282 002 (India). 3-methyl pyrazolone derivatives have their importance due to variety of industrial applications and wide range of biological activities have been synthesized by two different methods ( conventional heating and microwave irradiation ) and compare these method in terms of yield and time etc. using malon (R) anilic acid hydrazides (1a,1b) with ethyl 2,3-dioxobutyrate 2(RI ) phenyl hydrazono (a1-l1) were reacted in presence of glacial acetic acid to give 4(R I ) phenyl hydrazono - N1-(R) amino malonyl-3-methyl-pyrazol-5-ones and the synthesized compounds was purified by recrystallization from absolute ethanol. The synthesized compounds (2a,2c,2i,2k,3a, 3e,3g,3i) were found to have significant effect against S.aureus and E.coli micro-organism. The structures of the synthesized compounds have been characterized by their elemental analysis, colour, m.p, yield%, spectroscopic (IR, 1H NMR) technique. https://biomedpharmajournal.org/vol3no2/synthesis-spectral-evaluation-and-antimicrobial-screening-of-some-n1-substituted-3-methyl-pyrazol-5-ones-by-2-ways-a-comparative-study/ Pyrazolones Spectral studies Biological activity Microwave irradiation Comparison