eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-11-26 3 2 277 282 1506 article Elias Babarbi 1 Maammar Haffas 1 Messaoud Guerri 1 Lakhdar Sekhri 1 Department of Chemistry, Faculty of Sciences, University of Kasdi Merbah, Ouargla - 300 00 (Algeria). Tris (pentafluorophenyl) phosphine, bis (pentafuorophenyl) phenylphosphine, tris (4-fluorophenyl) phosphine and triphenylphosphine are readily reacted with an excess of methyl iodide in chloroform at boiling point to afford respectively phosphonium salts of methyl tris (pentafluorophenyl)phosphonium iodide, methyl bis (pentafuorophenyl)phenylphosphonium iodide, methyl tris (4-fluorophenyl) phosphonium iodide and methyl triphenylphosphonium iodide. These phosphonium salts showed significant activity against all the bacteria tested, Escherichia Coli, Protius, Staphylococcus Aureus and Pseudomonas. The combination of these phosphonium salts with the penicillin G or V gives a synergistic effect. https://biomedpharmajournal.org/vol3no2/synthesis-of-some-fluorinated-phosphonium-iodide-derivatives-study-of-their-biological-antibacterial-activities-and-the-effect-of-synergy-of-these-compounds-with-penicillin-g-and-penicillin-v/ (pentafluorophenyl) phosphine synergistic effect bacteria penicillin-G V