Minerals and metals of remedial value and their pharmaceutical processing techniques are dealt in Ayurvedic pharmaceutical science with a view to make them adoptable, nontoxic and efficacious. Toxicity of minerals and metals are proved information pharmaceutical processing techniques convert them into such a compound form, which acts as a safe and effective therapeutic agent. Shodhana (purification), Marana (incineration/calcinations) are the main pharmaceutical procedures by which raw and crude material converted in to high potent therapeutic agent. Pelletization (Chakrika nirmana) and Casserole sealing (Sarava samputikarana) are intermediary step of incineration processes which plays a significant role to establish S.O.P.of Ayurvedic bhasma.