As we know that ageing is the accumulation of changes in an organism or object over time. In human it refers to a multidimensional process of physical, psychological and social change. The detail description of such drugs which are used in prevention and management of ageing are scattered all over the Ayurvedic texts, amongst them Vayahsthapana Mahakashaya of Charaka Samhita is very important. Other drugs which are described in Jivaniya Mahakashaya, Brimhaniya Mahakashaya, Balya Mahakashaya, Rasayana and Vajikarana drugs are also useful for the prevention and management of ageing. According to Ayurveda main cause of ageing is Dhatukshaya, which is based on poshana level, agni level and shrotas level. So the Jivaniya, Brimhaniya, Balya, Rasayana and Vajikarana drugs may be most beneficial for the prevention and management of ageing.