Vernonia cinerea Less. of family Asteraceae is of medicinal value. In the present study pharmacognostical investigations such as morphology, physico-chemical parameters, powder characters, reaction of powder with chemical reagents and quantitative microscopy are carried out on the leaves of Vernonia cinerea Less. The Preliminary phytochemical screening revealed the presence of Flavonoids, Glycosides, Tannins, and Carbohydrates. The finding may provide useful information with regard to its identification and standardization in future.1