In this present study Cassia fistula (caesalpinaceae) fruits were extracted in 90% alcohol and water. The extract was vacuum evaporate to driness which yield 26.02% The extract was evaluated for hepato protective activity against CCI4 induced liver damage 50m/g 100mg/kg body weight. The biochemical parameter observed in the serum were Asparate transminase (AST), Alanine transaminase (AST), Alkaline phosphatase (AST), total protein and total lipid, Histopathologicla studies on the liver tissue were also performed. The extract exhibited dose dependent reduction in (AST), ALT and ALP and increase in total protein levels. Extracts thus Cassia fistula extract attenuates the hepatotoxic effect of CCI4.