eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-16 2 2 363 368 860 article Jyoti Dwivedi 1 Purnima Dey Sarkar 2 Department of Biochemistry, S.S. Medical College Rewa - 486 001 (India). Department of Biochemistry, N.S.C.B. Medical College Jabalpur - 482 003 (India). Imbalance in oxidant/antioxidant status is well document in patients with nephrotic syndrome & secondary nephrotic syndrome. Serum total antioxidant capacity, malondialdehyde, homocysteine, copper, zinc, plasma vitamin C were estimated in 2 groups, group I comprised of 50 nephrotic syndrome patients and group II comprised of 41 secondary nephrotic syndrome patients. It was observed there were decreased level of serum total antioxidant capacity (P<0.0001), copper (P<0.02), zinc (P<0.02), plasma vitamin C (P<0.0001) and increased serum level of malondialdehyde, homocysteine (P<0.0001) in secondary nephrotic group II when compared to nephrotic group I. Serum homocysteine were significantly positive correlated with MDA, negative correlated with serum Cu & Zn in nephrotic group. In conclusion increased oxidative stress in secondary nephrotic syndrome than nephrotic syndrome. Hyperhomocyst(e)inemia is related to decrease concentration of copper, zinc and supported to oxidative stress & endothelial dysfunction in nephrotic syndrome and secondary nephrotic syndrome. https://biomedpharmajournal.org/vol2no2/oxidative-stress-in-secondary-nephrotic-syndrome-recent-advances-with-homocysteine-copper-and-zinc/ Nephrotic Syndrome Total antioxidant capacity Homocysteine Malondialdehyde