eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-16 2 2 351 355 829 article T. Karthiyayini 1 Rajesh Kumar 1 K.L. Senthil Kumar 1 Ram Kumar Sahu 2 Amit Roy 3 Department of Pharmacognosy, Padmavathi College of Pharmacy, Dharmapuri (India). Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal (India) Columbia College of Pharmacy, Mandhar, Raipur (India). In order to evaluate the antidiabetic activity of powder fruit of Cucumis sativus. The different doses of ethanol extract were screened for their effects on serum glucose levels in streptozotocin-induced rats and lipid profile (biochemical parameters) in blood were also observed with histopathological studies. The oral administration of 200 and 400 mg/kg body weight of ethanol extracts of powder fruit of Cucumis sativus exhibited significant antidiabetic effects in streptozotocin induced rats as compared to standard drug. In the same study the action of the extracts on diabetes induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated cholesterol as well as LDL level. The drug has the potential to act as antidiabetic as well as antihyperlipidemic. The study revels that ethanol extract at dose of 400 mg/kg body weight exhibited more significant antidiabetic activity. https://biomedpharmajournal.org/vol2no2/evaluation-of-antidiabetic-and-hypolipidemic-effect-of-cucumis-sativus-fruit-in-streptozotocin-induced-diabetic-rats/ Antidiabetic Lipid profile Cucumis sativus Strepozotocin Glibenclamide